diff --git a/comfy/ops.py b/comfy/ops.py
index 14599997b..314ba005b 100644
--- a/comfy/ops.py
+++ b/comfy/ops.py
@@ -1151,7 +1151,10 @@ def _load_quantized_module(module, super_load, state_dict, prefix, local_metadat
 
     layer_conf = state_dict.pop(f"{prefix}comfy_quant", None)
     if layer_conf is not None:
-        layer_conf = json.loads(layer_conf.numpy().tobytes())
+        raw_conf = layer_conf.numpy().tobytes()
+        # Some quantizers mark unquantized layers with an all-NUL comfy_quant
+        # placeholder instead of omitting it; treat that the same as absent.
+        layer_conf = json.loads(raw_conf) if raw_conf.strip(b"\x00") else None
 
     if layer_conf is None:
         module.weight = torch.nn.Parameter(weight.to(device=device, dtype=compute_dtype), requires_grad=False)
@@ -1587,7 +1590,10 @@ def mixed_precision_ops(quant_config={}, compute_dtype=torch.bfloat16, full_prec
                 weight_key = f"{prefix}weight"
                 layer_conf = state_dict.pop(f"{prefix}comfy_quant", None)
                 if layer_conf is not None:
-                    layer_conf = json.loads(layer_conf.numpy().tobytes())
+                    raw_conf = layer_conf.numpy().tobytes()
+                    # Some quantizers mark unquantized layers with an all-NUL comfy_quant
+                    # placeholder instead of omitting it; treat that the same as absent.
+                    layer_conf = json.loads(raw_conf) if raw_conf.strip(b"\x00") else None
 
                 # Only fp8 and int8_tensorwise support per-row dequant via index select.
                 # Block-scaled formats (NVFP4, MXFP8) can't do per-row lookup efficiently.
diff --git a/tests-unit/comfy_quant/test_mixed_precision.py b/tests-unit/comfy_quant/test_mixed_precision.py
index 7bbc96616..f697eaf8c 100644
--- a/tests-unit/comfy_quant/test_mixed_precision.py
+++ b/tests-unit/comfy_quant/test_mixed_precision.py
@@ -228,6 +228,33 @@ class TestMixedPrecisionOps(unittest.TestCase):
         with self.assertRaises(KeyError):
             model.load_state_dict(state_dict, strict=False)
 
+    def test_all_nul_comfy_quant_marker_loads_as_unquantized(self):
+        """Some quantizers mark unquantized layers with an all-NUL comfy_quant
+        placeholder instead of omitting the key; it must load as plain weight,
+        not crash decoding it as JSON or raise for a missing format."""
+        state_dict = {
+            "layer1.weight": torch.randn(20, 10, dtype=torch.bfloat16),
+            "layer1.bias": torch.randn(20, dtype=torch.bfloat16),
+            "layer1.comfy_quant": torch.zeros(29, dtype=torch.uint8),
+            "layer2.weight": torch.randn(30, 20, dtype=torch.bfloat16),
+            "layer2.bias": torch.randn(30, dtype=torch.bfloat16),
+            "layer3.weight": torch.randn(40, 30, dtype=torch.bfloat16),
+            "layer3.bias": torch.randn(40, dtype=torch.bfloat16),
+        }
+
+        model = SimpleModel(operations=ops.mixed_precision_ops({}))
+        model.load_state_dict(state_dict, strict=False)
+
+        self.assertNotIsInstance(model.layer1.weight, QuantizedTensor)
+
+        for layer in [model.layer1, model.layer2, model.layer3]:
+            layer.weight_function = []
+            layer.bias_function = []
+
+        input_tensor = torch.randn(5, 10, dtype=torch.bfloat16)
+        output = model(input_tensor)
+        self.assertEqual(output.shape, (5, 40))
+
     def test_int8_convrot_metadata_loads_into_params(self):
         """ConvRot metadata must reach TensorWiseINT8Layout params."""
         torch.manual_seed(123)