diff --git a/tests/test_downloadermiddleware.py b/tests/test_downloadermiddleware.py
index 79f24c8a1..55af4c240 100644
--- a/tests/test_downloadermiddleware.py
+++ b/tests/test_downloadermiddleware.py
@@ -1,11 +1,12 @@
 import asyncio
-from unittest import mock
+from unittest import mock, SkipTest
 
 from pytest import mark
 from twisted.internet import defer
 from twisted.internet.defer import Deferred
 from twisted.trial.unittest import TestCase
 from twisted.python.failure import Failure
+from twisted.python.versions import Version
 
 from scrapy.http import Request, Response
 from scrapy.spiders import Spider
@@ -211,10 +212,24 @@ class MiddlewareUsingDeferreds(ManagerTestCase):
         self.assertFalse(download_func.called)
 
 
+@mark.usefixtures('reactor_pytest')
 class MiddlewareUsingCoro(ManagerTestCase):
     """Middlewares using asyncio coroutines should work"""
 
     def test_asyncdef(self):
+        import twisted
+        if (
+            self.reactor_pytest == 'asyncio'
+            and twisted.version < Version('twisted', 18, 4, 0)
+        ):
+            raise SkipTest(
+                'Due to https://twistedmatrix.com/trac/ticket/9390, this test '
+                'hangs when using AsyncIO and Twisted versions lower than '
+                '18.4.0'
+            )
+
+        from twisted.python.versions import Version
+
         resp = Response('http://example.com/index.html')
 
         class CoroMiddleware: