diff --git a/scrapy/tests/test_utils_url.py b/scrapy/tests/test_utils_url.py
index a47bb883d..959760068 100644
--- a/scrapy/tests/test_utils_url.py
+++ b/scrapy/tests/test_utils_url.py
@@ -17,6 +17,10 @@ class UrlUtilsTest(unittest.TestCase):
         self.assertTrue(url_is_from_any_domain(url, ['wheele-bin-art.co.uk']))
         self.assertFalse(url_is_from_any_domain(url, ['art.co.uk']))
 
+        url = 'http://www.Wheele-Bin-Art.co.uk/get/product/123'
+        self.assertTrue(url_is_from_any_domain(url, ['wheele-bin-art.CO.UK']))
+        self.assertTrue(url_is_from_any_domain(url, ['WHEELE-BIN-ART.CO.UK']))
+
         url = 'http://192.169.0.15:8080/mypage.html'
         self.assertTrue(url_is_from_any_domain(url, ['192.169.0.15:8080']))
         self.assertFalse(url_is_from_any_domain(url, ['192.169.0.15']))
diff --git a/scrapy/utils/url.py b/scrapy/utils/url.py
index 918042064..9a12aa26b 100644
--- a/scrapy/utils/url.py
+++ b/scrapy/utils/url.py
@@ -17,10 +17,10 @@ from scrapy.utils.python import unicode_to_str
 
 def url_is_from_any_domain(url, domains):
     """Return True if the url belongs to any of the given domains"""
-    host = parse_url(url).netloc
+    host = parse_url(url).netloc.lower()
 
     if host:
-        return any(((host == d) or (host.endswith('.%s' % d)) for d in domains))
+        return any(((host == d.lower()) or (host.endswith('.%s' % d.lower())) for d in domains))
     else:
         return False