diff --git a/scrapy/utils/misc.py b/scrapy/utils/misc.py
index 4d4fb9600..e0f7ca9e5 100644
--- a/scrapy/utils/misc.py
+++ b/scrapy/utils/misc.py
@@ -9,6 +9,7 @@ from collections import deque
 from contextlib import contextmanager
 from importlib import import_module
 from pkgutil import iter_modules
+from functools import partial
 
 from w3lib.html import replace_entities
 
@@ -226,7 +227,11 @@ def is_generator_with_return_value(callable):
         return value is None or isinstance(value, ast.NameConstant) and value.value is None
 
     if inspect.isgeneratorfunction(callable):
-        src = inspect.getsource(callable)
+        func = callable
+        while isinstance(func, partial):
+            func = func.func
+
+        src = inspect.getsource(func)
         pattern = re.compile(r"(^[\t ]+)")
         code = pattern.sub("", src)
 
diff --git a/tests/test_utils_misc/test_return_with_argument_inside_generator.py b/tests/test_utils_misc/test_return_with_argument_inside_generator.py
index 72277d701..562f72fee 100644
--- a/tests/test_utils_misc/test_return_with_argument_inside_generator.py
+++ b/tests/test_utils_misc/test_return_with_argument_inside_generator.py
@@ -1,5 +1,6 @@
 import unittest
 import warnings
+from functools import partial
 from unittest import mock
 
 from scrapy.utils.misc import is_generator_with_return_value, warn_on_generator_with_return_value
@@ -254,3 +255,10 @@ https://example.org
             warn_on_generator_with_return_value(None, top_level_return_none)
             self.assertEqual(len(w), 1)
             self.assertIn('Unable to determine', str(w[0].message))
+
+    def test_partial(self):
+        def cb(arg1, arg2):
+            yield {}
+
+        partial_cb = partial(cb, arg1=42)
+        assert not is_generator_with_return_value(partial_cb)