diff --git a/docs/intro/install.rst b/docs/intro/install.rst
index fda0d7058..4f7aa52be 100644
--- a/docs/intro/install.rst
+++ b/docs/intro/install.rst
@@ -13,7 +13,7 @@ Requirements
 
 * `Python`_ 2.6, 2.7 (3.x is not yet supported)
 
-* `Twisted`_ 2.5.0, 8.0 or above (Windows users: you'll need to install
+* `Twisted`_ 8.0 or above (Windows users: you'll need to install
   `Zope.Interface`_ and maybe `pywin32`_ because of `this Twisted bug`_)
 
 * `w3lib`_
diff --git a/scrapy/__init__.py b/scrapy/__init__.py
index 99c366eb7..76f704f7a 100644
--- a/scrapy/__init__.py
+++ b/scrapy/__init__.py
@@ -15,7 +15,7 @@ if sys.version_info < (2,6):
 warnings.filterwarnings('ignore', category=DeprecationWarning, module='twisted')
 
 # monkey patches to fix external library issues
-from scrapy.xlib import twisted_250_monkeypatches, urlparse_monkeypatches
+from scrapy.xlib import urlparse_monkeypatches
 
 # optional_features is a set containing Scrapy optional features
 optional_features = set()
diff --git a/scrapy/xlib/twisted_250_monkeypatches.py b/scrapy/xlib/twisted_250_monkeypatches.py
deleted file mode 100644
index 56dc93f31..000000000
--- a/scrapy/xlib/twisted_250_monkeypatches.py
+++ /dev/null
@@ -1,49 +0,0 @@
-"""
-Monkey patches for supporting Twisted 2.5.0
-
-NOTE: This module must not fail if twisted module is not available.
-"""
-
-# This function comes bundled with Twisted 8.x and above
-def add_missing_blockingCallFromThread():
-    import Queue
-    from twisted.internet import defer
-    from twisted.python import failure
-
-    def blockingCallFromThread(reactor, f, *a, **kw):
-        """
-        Run a function in the reactor from a thread, and wait for the result
-        synchronously, i.e. until the callback chain returned by the function
-        get a result.
-
-        @param reactor: The L{IReactorThreads} provider which will be used to
-            schedule the function call.
-        @param f: the callable to run in the reactor thread
-        @type f: any callable.
-        @param a: the arguments to pass to C{f}.
-        @param kw: the keyword arguments to pass to C{f}.
-
-        @return: the result of the callback chain.
-        @raise: any error raised during the callback chain.
-        """
-        queue = Queue.Queue()
-        def _callFromThread():
-            result = defer.maybeDeferred(f, *a, **kw)
-            result.addBoth(queue.put)
-        reactor.callFromThread(_callFromThread)
-        result = queue.get()
-        if isinstance(result, failure.Failure):
-            result.raiseException()
-        return result
-
-    from twisted.internet import threads
-    threads.blockingCallFromThread = blockingCallFromThread
-
-try:
-    import twisted
-    from twisted.python.versions import Version
-    if twisted.version < Version("twisted", 8, 0, 0):
-        add_missing_blockingCallFromThread()
-except ImportError:
-    pass
-
diff --git a/setup.py b/setup.py
index 069c8cdf0..7bcd127a4 100644
--- a/setup.py
+++ b/setup.py
@@ -120,7 +120,7 @@ try:
 except ImportError:
     from distutils.core import setup
 else:
-    setup_args['install_requires'] = ['Twisted>=2.5', 'w3lib>=1.1', 'pyOpenSSL']
+    setup_args['install_requires'] = ['Twisted>=8.0', 'w3lib>=1.1', 'pyOpenSSL']
     if sys.version_info < (2, 6):
         setup_args['install_requires'] += ['simplejson']
     try: