diff --git a/scrapy/pipelines/files.py b/scrapy/pipelines/files.py
index c757b0a3f..45ceddcbb 100644
--- a/scrapy/pipelines/files.py
+++ b/scrapy/pipelines/files.py
@@ -29,6 +29,7 @@ from scrapy.utils.log import failure_to_exc_info
 from scrapy.utils.python import to_bytes
 from scrapy.utils.request import referer_str
 from scrapy.utils.boto import is_botocore
+from scrapy.utils.datatypes import CaselessDict
 
 logger = logging.getLogger(__name__)
 
@@ -137,13 +138,17 @@ class S3FilesStore(object):
         key_name = '%s%s' % (self.prefix, path)
         buf.seek(0)
         if self.is_botocore:
+            extra = self._headers_to_botocore_kwargs(self.HEADERS)
+            if headers:
+                extra.update(self._headers_to_botocore_kwargs(headers))
             return threads.deferToThread(
                 self.s3_client.put_object,
                 Bucket=self.bucket,
                 Key=key_name,
                 Body=buf,
                 Metadata={k: str(v) for k, v in six.iteritems(meta)},
-                ACL=self.POLICY)
+                ACL=self.POLICY,
+                **extra)
         else:
             b = self._get_boto_bucket()
             k = b.new_key(key_name)
@@ -157,6 +162,35 @@ class S3FilesStore(object):
                 k.set_contents_from_string, buf.getvalue(),
                 headers=h, policy=self.POLICY)
 
+    def _headers_to_botocore_kwargs(self, headers):
+        """ Convert headers to botocore keyword agruments.
+        """
+        # This is required while we need to support both boto and botocore.
+        mapping = CaselessDict({
+            'Content-Type': 'ContentType',
+            'Cache-Control': 'CacheControl',
+            'Content-Disposition': 'ContentDisposition',
+            'Content-Encoding': 'ContentEncoding',
+            'Content-Language': 'ContentLanguage',
+            'Content-Length': 'ContentLength',
+            'Content-MD5': 'ContentMD5',
+            'Expires': 'Expires',
+            'X-Amz-Grant-Full-Control': 'GrantFullControl',
+            'X-Amz-Grant-Read': 'GrantRead',
+            'X-Amz-Grant-Read-ACP': 'GrantReadACP',
+            'X-Amz-Grant-Write-ACP': 'GrantWriteACP',
+            })
+        extra = {}
+        for key, value in six.iteritems(headers):
+            try:
+                kwarg = mapping[key]
+            except KeyError:
+                raise TypeError(
+                    'Header "%s" is not supported by botocore' % key)
+            else:
+                extra[kwarg] = value
+        return extra
+
 
 class FilesPipeline(MediaPipeline):
     """Abstract pipeline that implement the file downloading
diff --git a/scrapy/utils/test.py b/scrapy/utils/test.py
index 43abd64a0..bf66a8cbe 100644
--- a/scrapy/utils/test.py
+++ b/scrapy/utils/test.py
@@ -26,7 +26,7 @@ def skip_if_no_boto():
     except NotConfigured as e:
         raise SkipTest(e.message)
 
-def get_s3_content_and_delete(bucket, path):
+def get_s3_content_and_delete(bucket, path, with_key=False):
     """ Get content from s3 key, and delete key afterwards.
     """
     if is_botocore():
@@ -43,7 +43,7 @@ def get_s3_content_and_delete(bucket, path):
         key = bucket.get_key(path)
         content = key.get_contents_as_string()
         bucket.delete_key(path)
-    return content
+    return (content, key) if with_key else content
 
 def get_crawler(spidercls=None, settings_dict=None):
     """Return an unconfigured Crawler object. If settings_dict is given, it
diff --git a/tests/test_pipeline_files.py b/tests/test_pipeline_files.py
index e445d9989..77e75d5ac 100644
--- a/tests/test_pipeline_files.py
+++ b/tests/test_pipeline_files.py
@@ -16,6 +16,7 @@ from scrapy.http import Request, Response
 from scrapy.settings import Settings
 from scrapy.utils.python import to_bytes
 from scrapy.utils.test import assert_aws_environ, get_s3_content_and_delete
+from scrapy.utils.boto import is_botocore
 
 from tests import mock
 
@@ -194,14 +195,27 @@ class TestS3FilesStore(unittest.TestCase):
         meta = {'foo': 'bar'}
         path = ''
         store = S3FilesStore(uri)
-        yield store.persist_file(path, buf, info=None, meta=meta)
+        yield store.persist_file(
+            path, buf, info=None, meta=meta,
+            headers={'Content-Type': 'image/png'})
         s = yield store.stat_file(path, info=None)
         self.assertIn('last_modified', s)
         self.assertIn('checksum', s)
         self.assertEqual(s['checksum'], '3187896a9657a28163abb31667df64c8')
         u = urlparse(uri)
-        content = get_s3_content_and_delete(u.hostname, u.path[1:])
+        content, key = get_s3_content_and_delete(
+            u.hostname, u.path[1:], with_key=True)
         self.assertEqual(content, data)
+        if is_botocore():
+            self.assertEqual(key['Metadata'], {'foo': 'bar'})
+            self.assertEqual(
+                key['CacheControl'], S3FilesStore.HEADERS['Cache-Control'])
+            self.assertEqual(key['ContentType'], 'image/png')
+        else:
+            self.assertEqual(key.metadata, {'foo': 'bar'})
+            self.assertEqual(
+                key.cache_control, S3FilesStore.HEADERS['Cache-Control'])
+            self.assertEqual(key.content_type, 'image/png')
 
 
 class ItemWithFiles(Item):