diff --git a/scrapy/spiders/crawl.py b/scrapy/spiders/crawl.py
index d860ae0b4..edac082d0 100644
--- a/scrapy/spiders/crawl.py
+++ b/scrapy/spiders/crawl.py
@@ -6,11 +6,12 @@ See documentation in docs/topics/spiders.rst
 """
 
 import copy
-from typing import Awaitable, Sequence
+from typing import AsyncIterable, Awaitable, Sequence
 
-from scrapy.http import Request, HtmlResponse
+from scrapy.http import Request, Response, HtmlResponse
 from scrapy.linkextractors import LinkExtractor
 from scrapy.spiders import Spider
+from scrapy.utils.asyncgen import collect_asyncgen
 from scrapy.utils.spider import iterate_spider_output
 
 
@@ -78,7 +79,7 @@ class CrawlSpider(Spider):
     def parse_start_url(self, response, **kwargs):
         return []
 
-    def process_results(self, response, results):
+    def process_results(self, response: Response, results: list):
         return results
 
     def _build_request(self, rule_index, link):
@@ -112,7 +113,9 @@ class CrawlSpider(Spider):
     async def _parse_response(self, response, callback, cb_kwargs, follow=True):
         if callback:
             cb_res = callback(response, **cb_kwargs) or ()
-            if isinstance(cb_res, Awaitable):
+            if isinstance(cb_res, AsyncIterable):
+                cb_res = await collect_asyncgen(cb_res)
+            elif isinstance(cb_res, Awaitable):
                 cb_res = await cb_res
             cb_res = self.process_results(response, cb_res)
             for request_or_item in iterate_spider_output(cb_res):
diff --git a/scrapy/utils/asyncgen.py b/scrapy/utils/asyncgen.py
index 9f794de92..c84b51e8c 100644
--- a/scrapy/utils/asyncgen.py
+++ b/scrapy/utils/asyncgen.py
@@ -1,7 +1,7 @@
 from typing import AsyncGenerator, AsyncIterable, Iterable, Union
 
 
-async def collect_asyncgen(result: AsyncIterable):
+async def collect_asyncgen(result: AsyncIterable) -> list:
     results = []
     async for x in result:
         results.append(x)
diff --git a/tests/spiders.py b/tests/spiders.py
index 2b78e1f7c..5ea8a4a21 100644
--- a/tests/spiders.py
+++ b/tests/spiders.py
@@ -381,6 +381,18 @@ class CrawlSpiderWithAsyncCallback(CrawlSpiderWithParseMethod):
         return Request(self.mockserver.url("/status?n=202"), self.parse_async, cb_kwargs={"foo": "bar"})
 
 
+class CrawlSpiderWithAsyncGeneratorCallback(CrawlSpiderWithParseMethod):
+    """A CrawlSpider with an async generator callback"""
+    name = 'crawl_spider_with_async_generator_callback'
+    rules = (
+        Rule(LinkExtractor(), callback='parse_async_gen', follow=True),
+    )
+
+    async def parse_async_gen(self, response, foo=None):
+        self.logger.info('[parse_async_gen] status %i (foo: %s)', response.status, foo)
+        yield Request(self.mockserver.url("/status?n=202"), self.parse_async_gen, cb_kwargs={"foo": "bar"})
+
+
 class CrawlSpiderWithErrback(CrawlSpiderWithParseMethod):
     name = 'crawl_spider_with_errback'
     rules = (
diff --git a/tests/test_crawl.py b/tests/test_crawl.py
index d14021319..8be4b6fe1 100644
--- a/tests/test_crawl.py
+++ b/tests/test_crawl.py
@@ -38,6 +38,7 @@ from tests.spiders import (
     BytesReceivedCallbackSpider,
     BytesReceivedErrbackSpider,
     CrawlSpiderWithAsyncCallback,
+    CrawlSpiderWithAsyncGeneratorCallback,
     CrawlSpiderWithErrback,
     CrawlSpiderWithParseMethod,
     DelaySpider,
@@ -402,6 +403,16 @@ class CrawlSpiderTestCase(TestCase):
         self.assertIn("[parse_async] status 201 (foo: None)", str(log))
         self.assertIn("[parse_async] status 202 (foo: bar)", str(log))
 
+    @defer.inlineCallbacks
+    def test_crawlspider_with_async_generator_callback(self):
+        crawler = get_crawler(CrawlSpiderWithAsyncGeneratorCallback)
+        with LogCapture() as log:
+            yield crawler.crawl(mockserver=self.mockserver)
+
+        self.assertIn("[parse_async_gen] status 200 (foo: None)", str(log))
+        self.assertIn("[parse_async_gen] status 201 (foo: None)", str(log))
+        self.assertIn("[parse_async_gen] status 202 (foo: bar)", str(log))
+
     @defer.inlineCallbacks
     def test_crawlspider_with_errback(self):
         crawler = get_crawler(CrawlSpiderWithErrback)